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Objective To teach the intellectuals how to adapt psychological stress and improve health by rational nutrition and health education. Method The propaganda and education on the role of nutrients in increasing the adaptive ability to psychological stress and ameliorating related diseases were used, mainly in the way of seminar and consultation, and the psychological status was evaluated by testing A-type behavior, anxiety and depression, and determining the concentration of saliva cortisol, serum homocysteine and lipid peroxides. Results After education, A type behavior, SDS total scores and the concentration of saliva cortisol, serum homocysteine and lipid peroxides were decreased dramatically, indicating that the psychological stress of intellectuals was effectively reliveved. Conclusion Nutritional propaganda and education can significantly improve intellectuals’ psychological health status.
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Objective: To observe the effects of nutrients-compound supplementation (NS) on cognitive function. Method: Forty six young male volunteers were randomly divided into 2 groups, NS and control (CT). NS group was supplemented with nutrients-compound while CT group received placebo for 60 d.The cognitive function of all volunteers were examined by 《CHANG-AN Handbook of Group Intelligence Test》 and Wechsler Memory Scale(WMS). Their vitamin status was assessed by 4-h load test at the end of experiment. Results : The vitamin nutriture of NS group was significantly better than that of CT. Many achievements of cognitive test of NS group were obviously increased compared to that before supplementation or that of CT. The visual responding time was shortened in 3 tests and the error number was decreased in 1 test of NS group, while no significant change was observed in CT group. Conclusion: Supplementation with the nutrients-compound is beneficial to improvement of cognitive function such as learning, memory and understanding.
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Objective:To study the effects of zinc deficiency on bone histomorphometric parameters of femoral distal diaphysis in rats. Methods:Thirty Wistar rats were randomly allocated into three groups:the zinc-deficient group(ZD), the control group(Cont),and the pair-fed group(ZP). After the rats had been fed for eight weeks, the histomorphometric and dynamic parameters of the rats were analysed using bone histomorphometric method. Results:The number, volume and connectivity of trabecular bone, and the mean trabecular plate density of ZD rats were significantly decreased, but their mean trabecular plate space was significantly increased. In addition, the data showed that ZD animals had significantly decreased trabecular osteoid surface, reduced velocity of bone formation as compared with Cont and ZP animals. The results showed that in ZD rats the mineral deposit rate was significantly slow, while the mineralization lag and osteoid maturation period were obviously prolonged. Conclusion: Zinc deficiency reduces velocity of bone formation and prolongs bone mineralization and destroys bone structure.
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Objective To observe the effects of psychological stress on the levels of Hcy and folate in rats. Method The Wistar rats were randomly assigned to three groups as follows:control,stress and stress with folate supplement. The animal model of psychological stress was developed by restraint. Results The levels of Hcy both in plasma and cerebrospinal fluid were increased and not only the level of folate in plasma but also in cortex,hippocampus,liver and mucous membrane epithelium of small intestine were decreased under restraint stress. Folate supplement could improve the depletion of folate and the increase of Hcy induced by restraint. Conclusion The depletion of folate may be one of the important factors of high Hcy level induced by psychological stress.
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Objective: To explore the effects of different doses of Zn on the expression of metallo- thionein(MT) isoforms in hippocampus, olfactory bulb, diencephalon and cortex in stress rats. Method: The animal model of psychological stress was developed by restraint for 4w. Wistar rats were randomly assigned to 8 groups: control group, Zn-deficient group, pair-fed group, Zn -supplemented group and their corresponding stress groups. The expressions of MTs and their mRNAs were detected by Western blot and RT-PCR respectively. Results: In Zn-deficient group, plasma zinc content was decreased, while in Zn -supplemented group slightly increased. Compared with Zn-deficient group, the stress Zn -deficient group had higher expressions of MTs and MT-1 mRNA, MT-3 mRNA in hippocampus, olfactory bulb, diencephalon and cortex. Expressions of MTs in Zn-supplemented group were increased, and much more in corresponding stress group. In addition, the levels of plasma cortisol, IL-6 and IL-1 were increased clearly in Zn-deficient group and stress groups. Moreover, MTs’ productions were different in four brain domains,the highest in hippocampus and the lowest in diencephalon. Conclusion: Zn may affect the expressions of MTs and MT-1 mRNA, MT-3 mRNA in different regions of brain in stress rats. The higher production of MTs in hippocampus may be related to its role in body’s adaptation to stress. Cortisol, IL-6 and IL-1 may be involved in the modulation of expression of MTs.
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Objective: To observe the effects of vitamin A (VA)-fortified edible oil on improving the immune function of children. Method: The marginally VA-deficient children were selected as volunteers in four cities of China. Nutritional intervention was conducted in the children with edible oil fortified with VA 7500?g/kg for five months. The VA level, the contents of IgA,IgG,IgM and complement C3 in sera of the volunteers were detected at the end of intervention. Results: The levels of VA, IgA,and C3 in sera of the intervention group were significantly higher than those of the control group, but no differences of IgG and IgM were observed. Conclusion:The VA status and immune function of the AD children could be effectively improved with vitamin A-fortified edible oil.
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Objective: To study the effects of different niacin nutritures on behaviors of stressed rats. Methods: 100 Wistar male rats were assigned into 10 groups:control, pair-fed, nicotinamide (NAM) deficiency (ND), low-dose NAM supplement (LNS 40 mg/kg diet) and high-dose NAM supplement (HNS 500 mg/kg diet), and the corresponding restrained groups. 24 h urinary excretion of N1-methylnicotinamide (NMN), body weight changes, behaviors in the open-field test, plasma cortisol, nitric oxide(NO) and liver nitric oxide synthase(NOS) were determined. Results: Compared with the control group, restrained rats had relatively lower urinary NMN. Both ND and restrainted stress retarded the body weight gains . Rats in the control and LNS groups had relatively shorter latency time in the open-field test. Restrained rats had higher plasma cortisol and NO than those in the corresponding control group. However, rats with HNS had the lowest plasma cortisol concentrations. Dietary supplement of NAM increased liver NOS . Conclusions: Restraint stress may increase niacin depletion and appropriate NAM supplement has positive effects on stress adaptation in rats.
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The effects of 4 kinds of edible oils on serum lipid levels, morphological changes of cardiovascular tissues, fatty acid compositions of various tissues and platelet function in rats had been observed. 40 adult Wistar rats fed semi-synthetic diet containing edible oil to supply 41% energy were divided into 5 group, i. e. control group (18.7% energy from fat), soy bean oil group, peanut oil group, lard group and rape seed oil group. The animals were fed the diets and water ad libitum for 2 months. The results showed that the lard gave the most serious detrimental effect but the soy bean oil was the least. The difference between these two groups was significant. The platelet number was 223?109/L and aggregation rate was 21.8% of the soy bean oil group but. the lard group 149?109/L and 30.2%. The composition (%) of PUFA in tissues was higher and that of saturated fatty acid was tower in soy bean ou group than those in lard group.Electron microscopical studies showed that the animals with vascular endothelial cells changes were more and the pathological changes were more serious in the lard group than those in the soy bean group.All groups except rape seed oil group increased weights in the experi-mental period at the similar rate. Rape seed oil group gained very little weights and aggregated more C22:1 especially in myocardium.
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For observation of the therapeutic effect of some foods on hyperlipi-demia in men, study was perfomed with subjects of hyperlipidemia by using mushroom, soya bean meat, beans, garlic, spring onions, prawn, chives, walnut seeds, peanut seeds, fishes etc. After 3 months treatment, the average values of serum total cholesterol and triglyceride were decreased significantly. The percentage of serum high-density lipoprotein cholesterol in the total cholesterol was increased from 24.7% to 31.3%; the percentage of serum low-density lipoprotein cholesterol was decreased from 61.8% to 49.2%. The curative rates of subjects with hypercholesterolemia were 93.3%, and the subjects with hypertriglyceridemia were only 50.0% and 57.1%. The effective rates were 79-87%.
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Objective: Three experiments were used to evaluate the effects of zinc deficiency on growth, learning and memory ability of rats. [WT5FZ]Methods: In experiment Ⅰ and experiment Ⅱ, the experimental rats were divided into three groups, which were zinc deficiency group (ZD), pair fed group (PF), and zinc deficiency and supplementation group (ZS). Their durations were 35 days and 28 days respectively. In experiment Ⅲ, the experimental rats were divided into ZD, PF and ad libitum (AL) group. Results: Zinc deficiency significantly decreased the growth and learning ability of rats, whereas zinc supplementation reversed the above status. Conclusion: The results suggest that zinc not only influence growth, but also the advanced function like learning and memory ability of brain.
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Objective:[WT5BZ]The effect of different contents of zinc in feed on learning and memory function and brain somatostatin,zinc and calcium concentrations in rats were studied. [WT5HZ]Methods:[WT5BZ]The feeds contained 20, 50, 100, 200, 400, 800 mg/kg zinc respectively.The learning and memory function of animals were determined by radioimmunoassay.Their zinc and calcium contents were determined by atomic absorption spectrophotometry. [WT5HZ]Results:[WT5BZ]Feeds containing 100 and 200 mg/kg zinc were adequate for learning and memory function of rats,whereas other feeds resulted in poor learning and memory function,and depression in somatostatin concentration in hypothalamus,hippocampus and cerebrum cortex.Additionally,feeds containing lower than 100 mg/kg zinc decreased zinc concentrations in blood,hippocampus,cerebrum cortex and hypothalamus,and calcium concentration in cerebrum cortex. [WT5HZ]Conclusion:[WT5BZ]These results suggest that 100 200 mg/kg zinc in feed is adequate for maintaining learning and memory function in rats.